Where is chromosome 7 located

A related article has been published: The enigma of monosomy 7. Cite Icon Cite. Conflict-of-interest disclosure: The authors declare no competing financial interests. Search ADS. Clinical, molecular, and prognostic significance of WHO type inv 3 q21q Le Beau. Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases.

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by SA8 and SA9. Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Add comment Close comment form modal. Submit a comment. Comment title. You have entered an invalid code. Submit Cancel. Thank you for submitting a comment on this article.

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PubMed is a searchable database of medical literature and lists journal articles that discuss Chromosome 7q deletion. Click on the link to view a sample search on this topic. Have a question? References References. De novo 7q deletion with a positive maternal serum triple test screening. J Obstet Gynaecol Res. February ; 34 1 Do you know of a review article? Share this content:. Close Copy Link. You May Be Interested In. How to Find a Disease Specialist. Tips for the Undiagnosed.

Support for Patients and Families. Tips for Finding Financial Aid. Help with Travel Costs. The work may benefit research in cystic fibrosis, deafness, B-cell lymphoma and other cancers, genes for which are found on chromosome 7. Also found there is the gene for P-glycoprotein, a protein that enables cancer cells to resist anticancer drugs.

Other important genes found on chromosome 7 include those that help control cell division and cell death, genes for taste and smell receptors and those involved in immune responses.

Chromosome 7 also has a relatively centrally located centromere, a small region found on all chromosomes that is important during cell division. Centromeres on other chromosomes sequenced so far are located near the tip of the chromosome, like a knob. The centromere on chromosome 7 divides the chromosome into a short arm and a long arm, both of which carry many genes. Sequencing proceeded from each end toward the centromere. The most challenging region of the chromosome to sequence was that containing genes for Williams-Beuren syndrome WBS , a rare genetic disorder characterized by mild mental retardation, unusual facial appearance and a narrowing of the aorta, the major artery leaving the heart.

The WBS region was difficult to decipher because it contains large segments DNA with many duplicated genes, and the number of duplicated genes differs among individuals. Children with WBS are missing long stretches of these duplicated genes.